Mathematical Programming for the Design and Analysis of a Biologics Facility
A journal article has been published in Biopharm International - "Mathematical Programming for the Design and Analysis of a Biologics Facility" by Donald Miller and Derrick Schertz of Advanced Process Combinatorics, Christopher Stevens of Bristol Myers Squibb, and Advanced Process Combinatorics Co-Founder and Purdue University Professor Joe Pekny. The article demonstrates the use of mathematical programming methods for automated schedule generation and the use of detailed schedules to support design and analysis. This article is Part 1 of a two part series, describing the use of math programming methods for automated generation of production schedules in a large industrial biologics facility. Part 1 describes the process and study results, and Part 2 will summarize the formulation, compare the approach to discrete event simulation and discuss the algorithmic solution methods to produce detailed production schedules. The case study includes storing of intermediate materials and bioreactor product, dropped lots, auxiliary activities, and a significant number of resource and precedence constraints.
The article may be read and printed at the Biopharm International Journal website.